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However, the FDA has received multiple reports of patients who have required medical attention, including hospitalization, after self-medicating with ivermectin intended for livestock. Ivermectin tablets are approved by the FDA to treat people with intestinal strongyloidiasis and onchocerciasis, two conditions caused by parasitic worms.
In addition, some topical forms of ivermectin are approved to treat external parasites like head lice and for skin conditions such as rosacea. Some forms of animal ivermectin are approved to prevent heartworm disease and treat certain internal and external parasites.
Ivermectin has not been shown to be safe or effective for these indications. It is not okay. But the authors stated clearly that the quality of the evidence was low and that the findings should be treated with caution. As is frequently the case for reviews of multiple small studies, the paper suggested that further trials were needed to determine whether ivermectin was indeed clinically effective.
One larger randomised clinical trial was published in March The authors stated that the findings did not support the use of ivermectin in these patients, but again highlighted that larger trials were needed to determine whether the drug had other benefits.
While some other studies did appear to show benefits of ivermectin, many did not. These were summarised by the National Institutes of Health , showing severe limitations arising from small sample sizes and problems with study design. Both the National Institutes of Health and the European Medicines Agency judged, on the basis of these studies, that there is currently insufficient evidence to support the use of ivermectin in treatment of COVID More studies are underway.
A large, multicentre trial began in February to determine the effectiveness of ivermectin as well as metformin an anti-diabetes medication and fluvoxamine an antidepressant in preventing COVID disease progression. It would therefore be premature to conclude absolutely that ivermectin has no place in COVID treatment.
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